Common Side Effects:
1. On the arm where you got the shot:
To reduce pain and discomfort where you got the shot:
- Apply a clean, cool, wet washcloth over the area.
- Use or exercise your arm.
2. Throughout the rest of your body:
- Muscle pain
To reduce discomfort from fever:
- Drink plenty of fluids.
- Dress lightly.
- Side effects can affect your ability to do daily activities, but they should go away in a few days.
- The most common reported side effect following vaccination is pain at the injection site.
- Trial data has shown that the Pfizer-BioNTech and Moderna vaccines are safe and generally well tolerated.
- With both mRNA COVID-19 vaccines (Pfizer-BioNTech COVID-19 Vaccine and Moderna COVID-19 Vaccine), you will need 2 shots in order to get the most protection. You should get the second shot even if you have side effects after the first shot, unless a vaccination provider or your doctor tells you not to get it.
- You will only need 1 shot of the viral vector COVID-19 vaccine, Johnson & Johnson’s Janssen COVID-19 Vaccine.
- It takes time for your body to build protection after any vaccination. COVID-19 vaccines that require 2 shots may not protect you until about 2 weeks after your second shot. For COVID-19 vaccines that require 1 shot, it takes about 2 weeks after vaccination for your body to build protection.
- No deaths from anaphylaxis following either vaccine have been reported.
- If you have a history of severe allergic reactions to vaccines, your doctor may advise you not to get the COVID-19 vaccine.
Now the FDA is reviewing another EUA request for a vaccine developed by Johnson & Johnson’s subsidiary company, Janssen Biotech.
All these vaccines appear to have mostly mild side effects that over-the-counter pain relievers can treat.
In rare cases, severe allergic reactions have been reported, but in all those cases, people were successfully treated.
If the FDA finds that Johnson & Johnson’s vaccine is safe and effective enough to distribute, that will drastically increase the stock of vaccine doses in the country.
“We are looking forward to it becoming available so that our vaccine supply can grow and synchronize with the demand,” said Dr. David Hirschwerk, an infectious disease specialist at Northwell Health in Manhasset, New York.
“But the FDA is extremely rigorous in their reviews. They will comb through the data methodically,” he said, “and are committed to seeing efficacy and safety demonstrated prior to issuing an [EUA].”
Safe Vaccines Have Some Mild Side Effects:
Before issuing EUAs for the Pfizer-BioNTech and Moderna COVID-19 vaccines, the FDA reviewed the available data from ongoing clinical trials.
Pfizer-BioNTech submitted data for people 16 years and older, while Moderna submitted findings for people 18 years and older.
The most common reported side effect following vaccination is pain at the injection site.
Some vaccine recipients also developed short-lived flu-like symptoms, such as fatigue, headache, body aches, chills, and fever.
Swollen lymph nodes have also been reported. These can appear as a lump in the armpit, which has worried some women who thought it could be a sign of breast cancer.
Trial data has shown that two doses of the Pfizer-BioNTech vaccine are 95 percent effective at preventing COVID-19, while two doses of the Moderna vaccine are 94 percent effective.
The trials have also found that both vaccines are safe and generally well tolerated.
Anaphylaxis is Rare and Treatable:
Anaphylaxis is a severe allergic reaction that can result from the vaccinations. It can be life threatening when not treated.
Since issuing EUAs for the Pfizer-BioNTech and Moderna vaccines, the federal government has continued to collect information about reported side effects, including rare cases of anaphylaxis or severe allergic reactions following vaccination.
The reported rate of anaphylaxis following vaccination with the Pfizer-BioNTech COVID-19 vaccine is 4.7 cases per million, while the reported rate for the Moderna vaccine is 2.5 cases per million.
No deaths from anaphylaxis following either vaccine have been reported.
When to Call the Doctor:
In most cases, discomfort from pain or fever is a normal sign that your body is building protection. Contact your doctor or healthcare provider:
- If the redness or tenderness where you got the shot gets worse after 24 hours
- If your side effects are worrying you or do not seem to be going away after a few days
- If you get a COVID-19 vaccine and you think you might be having a severe allergic reaction after leaving the vaccination site, seek immediate medical care by calling 911.
Additional Vaccines in the Pipeline:
Additional COVID-19 vaccines may soon become available in the United States, including vaccines from Johnson & Johnson and Oxford-AstraZeneca.
Johnson & Johnson submitted an EUA request for its vaccine on Feb. 4, and the FDA’s Vaccines and Related Biological Products Advisory Committee is scheduled to discuss later this EUA this month.
Researchers at AstraZeneca and Oxford University have also developed a vaccine against COVID-19. This vaccine has already been approved for use in the United Kingdom and several other countries, but the developers may not be ready to submit an EUA request to the FDA until this spring.
The Johnson & Johnson and Oxford-AstraZeneca vaccines appear to be somewhat less effective than the Pfizer-BioNTech and Moderna vaccines, but they have similar safety profiles and reported side effects such as sore arm, fever, or chills.
“These vaccines also appear to be very safe and also demonstrate injection site soreness as the main side effect,” Hirschwerk said.
Weighing the Benefits and Risks:
If you have certain health conditions, such as a history of severe allergic reaction to vaccines, your doctor may advise you not to get the COVID-19 vaccine.
But for most people, Hirschwerk said the benefits of getting vaccinated against COVID-19 “far outweigh” the risks.
“At this point, over 30 million Americans have received at least a single dose, and it has been very well tolerated and very effective,” he said.
“Severe side effects like anaphylaxis have proven to be extremely rare and, of course, are treatable,” he continued.
If you develop pain around the injection site after getting vaccinated, Smith said that applying ice or taking an over-the-counter pain reliever may help.
To ease flu-like symptoms following vaccination, she recommends taking anti-fever medication or a nonsteroidal anti-inflammatory drug (NSAID).
If you think you might be experiencing a severe allergic reaction to the vaccine, the Centers for Disease Control and Prevention recommends calling 911 or local emergency services for immediate medical attention.